Holy Spirit Integrated School started in a humble beginning through the mission of mother and son, Mrs. Mila T. Buenviaje and Dr. Jerome T. Buenviaje with the rest of the family members. The school was established in September 1997 but formally started its operations in June 1998. Pursuant to the requirements of DECS now DepEd, HSIS was organized and registered with the Securities and Exchange Commission (SEC) and was followed by the release of its Government Permit to operate for the Academic Year 1998-1999.
The first year of operations was inaugurated with 29 pupils in Pre-school, (N-K-P) to Grade Five. These 29 pupils gathered in a school house which now has been turned as the Administration Building. On the third year of the school, the student population increased to nearly 200% and a two-room Annex Building was built in the vacant lot. The following years were truly remarkable because of the consistent enormous growth of the student population. Thus, additional classrooms had been constructed gradually in the area.
For five years, HSIS was in operation through its Government Permit granted by the Department of Education which had to be renewed every school year. It was in Academic Year 2003-2004 when HSIS was granted by the DepEd, the Government Recognitions in Pre-school, Grade School, and High School which serve as its permanent license to operate. HSIS was also granted by the Bureau of Immigration an Authority to Accept Foreign Students through a Special Order issued in January 2006.
Now, HSIS is continuously making itself known in the City of Antipolo through its active participation and achievements in different academic and athletic competitions as well as various socio-civic activities.